Clxxvii. the Biological Inertness of Irradiated Mycosterols Other than Ergosterol. by Otto Rosenheim and Thomas Arthur
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Xcv. the Specificity of Ergosterol as Parent Substance of Vitamin D. by Otto Rosenheim and Thomas Arthur Webster
THE study of the antirachitic activity induced in various sterols by irradiation, which led to the discovery of ergosterol as the most potent source of vitamin D [Rosenheim and Webster, 1926; 1927, 1], has subsequently brought to light an interesting relationship between chemical structure and potential biological activity. The most characteristic general features of the sterol structure are th...
متن کاملLxxi. the Anti-rachitic Properties of Irradiated Sterols
IN a previous communication [1925] we have described the reasons which led us to the investigation of the action of ultra-violet light on sterols and brought evidence to show that irradiated cholesterol acquires anti-rachitic properties. We have since abundantly confirmed this discovery, which was made independently and almost simultaneously by the American investigators, Hess, Weinstock and He...
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Background: Due to abscopal effect, cell damage may occur outside of the radiation field and the quantification of this effect is one of the most challenging debates in radiation therapy. The aim of this study was to estimate the abscopal effect induced in non-irradiated tumors quantitatively by means of biological effective dose (BED). Materials and Methods: Breast tumors using 4T1 and MC4-L2 ...
متن کاملIsolation and Identification of Ergosterol and Mannitol from Aspergillus Fischeri*
Sterols are widely distributed in nature. It has been suggested that they be classified into three groups according to their occurrence : (1) zoosterols, the animal sterols (cholesterol, coprosterol) ; (2) phytosterols, the plant or vegetable sterols (sitosterol, stigmasterol) ; and (3) mycosterols, the sterols found in fungi (ergosterol, fungisterol). Although ergosterol has been detected in s...
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The chemistry of the activation products of irradiated ergosterol has been studied by numerous investigators. These investigations have been reviewed in considerable detail by Brockmann (1) and by Rosenberg (2). No studies have heretofore been reported on the chemistry of ergosterol activated by other means than ultraviolet light; however, the extensive use of preparations containing ergosterol...
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